Equipment for multiple breath washout

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Equipment for multiple breath washout.

5 Demeo DL, Campbell EJ, Barker AF, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. We read with interest the article ''Paediatrics in Berlin'' [1] in a recent issue of the European Respiratory Journal, which sum-marised the paediatric topics of the European Respiratory Society's Annual Congress in Berlin. In this article, inert gas mul...

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Validation of multiple-breath washout equipment: from bench to clinic and possible pitfalls.

much more widely used, such as spirometry, body plethysmography or T L CO . Before results of MBW can be compared between centres or even multi-centre trials can be performed, these kinds of validation studies are extremely important to guarantee comparability and identify sources of errors. In this regard, Gonem et al. [15] are to be congratulated for the thorough validation study of the Innoc...

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Correcting for tissue nitrogen excretion in multiple breath washout measurements

Nitrogen excreted from body tissues impacts the calculation of multiple breath nitrogen washout (MBWN2) outcomes. The aim of this study was to determine the effect of tissue N2 on MBWN2 outcomes in both healthy subjects and patients with CF and to assess whether it is possible to correct for tissue N2. The contribution of tissue N2 to MBWN2 outcomes was estimated by comparing MBWN2-derived func...

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A Systematic Approach to Multiple Breath Nitrogen Washout Test Quality

BACKGROUND Accurate estimates of multiple breath washout (MBW) outcomes require correct operation of the device, appropriate distraction of the subject to ensure they breathe in a manner representative of their relaxed tidal breathing pattern, and appropriate interpretation of the acquired data. Based on available recommendations for an acceptable MBW test, we aimed to develop a protocol to sys...

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Multiple Breath Nitrogen Washout: A Feasible Alternative to Mass Spectrometry

BACKGROUND The lung clearance index (LCI), measured by multiple breath washout (MBW), reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis (CF) lung disease. Current evidence is based on a customized mass spectrometry system that uses sulfur hexafluoride (SF6) as a tracer gas, which is not widely available. Nitrogen (N2) washout may be better suited for c...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2010

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00159509